منابع مشابه
Giant Proteins: Sensing Tension with Titin Kinase
Recent studies at the single-molecule level show how signaling from the giant protein titin can be triggered by direct mechanical activation of its kinase domain.
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Mechanosensitive channels sense and respond to changes in bilayer tension. In many respects, this is a unique property: the changes in membrane tension gate the channel, leading to the transient formation of open non-selective pores. Pore diameter is also high for the bacterial channels studied, MscS and MscL. Consequently, in cells, gating has severe consequences for energetics and homoeostasi...
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Homeostasis demands the integration and processing of a myriad of different input signals from a variety of sources. Regulation of central blood pressure is one such homeostatic system that depends critically on both volumetric and hemodynamic information. A common element for cardiovascular data transfer is sensing mechanical alterations such as cellular volume changes, changes in shear stress...
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The rapid worldwide spread of severe viral infections, often involving novel modifications of viruses, poses major challenges to our health care systems. This means that tools that can efficiently and specifically diagnose viruses are much needed. To be relevant for a broad application in local health care centers, such tools should be relatively cheap and easy to use. Here we discuss the bioph...
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ژورنال
عنوان ژورنال: Nature Methods
سال: 2015
ISSN: 1548-7091,1548-7105
DOI: 10.1038/nmeth.3726